Andor Sona 4.2

• 95% Quantum Efficiency
• 2048 x 2048 pixel array
• 1.6 e- (at any readout rate) Read Noise

Product Description

Sona is Andor’s latest high performance sCMOS camera platform, specifically for fluorescence microscopy. It launches with Sona 4.2B-11 and Sona 2.0B-11, each featuring 95% Quantum Efficiency (QE) and market-leading vacuum cooling to -45 °C.

Andor’s unique capability to deliver the ultimate in sCMOS sensitivity means signal to noise can be optimized in fluorescence microscopy under conditions of reduced excitation power, thus preserving living cells during extended measurement periods. The superior sensitivity of Sona also compliments reduction of fluorophore concentrations, thus minimally perturbing the cell’s physiology. Higher sensitivity means that exposure times can be shortened, facilitating faster frame rate measurements of dynamic processes, such as intracellular signalling mechanisms or cell motility. The ‘dual-amplifier’ approach to extended dynamic range is ideal for accurately imaging and quantifying challenging samples such as neurons. Furthermore, to achieve best-in-class quantification accuracy, Andor have implemented enhanced on-head intelligence to deliver market-leading linearity of > 99.7% across the whole dynamic range.

The flagship 4.2 Megapixel Sona 4.2B-11 model utilizes a unique technology approach that enables us to usefully access the entire 2048 x 2048 array, offering an impressive 32 mm sensor diagonal, harnessing the entire field of view available from the microscope. This is perfect for applications that require maximum information content, allowing large fields of cells, whole embryos or tissue samples to be captured with absolute clarity.

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Features and Benefits


95% QE & lowest noise


Prolong live cell observations / accurately measure physiology.

4.2 Megapixel & 32 mm F-mount
(Sona 4.2B-11)

Capture maximum field of cells, whole embryos and large tissue samples.

2.0 Megapixel and 22 mm C-mount
(Sona 2.0B-11)

Ideal for modern microscopes that have C-mount ports up to 22 mm. Readily adapt for use on 19 mm and 18 mm ports.

Easily adaptable to x60 and x40

Combine with the Magnifying Coupler Unit (MCU) – preserve optical clarity over a range of sample types.

Vacuum cooled to -450C

Very weak signals require lowest noise floor: Don’t be limited by camera thermal noise!

The ONLY vacuum back-illuminated

Andor’s proprietary UltraVacTM technology protects the sensor from (a) QE degradation, and
(b) moisture condensation.

48 fps (4.2 Megapixel);
70 fps (2.0 Megapixel)

Image highly dynamic samples without signal smear – e.g. cell motility, membrane
dynamics, ion flux, blood flow.

Extended Dynamic Range (EDR) mode

‘One snap quantification’ across a 53 000:1 signal range – measure challenging brightdim
samples such as neurons.

> 99.7% linearity

Market leading quantitative accuracy over the whole signal range – confidence of
measurement in any application where signal intensity indicates local concentration.

Anti-Glow Technology

Allows access to full 4.2 Megapixel array with long exposures – maximize field of view
and sensitivity.

User configurable ROI

Adapt to a range of microscope port sizes. Push frame rates and save data storage

Fan and water cooling as standard

Water cooling for maximum sensitivity and highly vibration sensitive set-ups, e.g.
super-resolution and electrophysiology.

USB 3.0 (‘USB 3.1 Gen 1’)•7

A convenient, high speed interface.