As a research led business we have been directly involved in a number of research projects which have resulted in journal articles, patents or other publications. Below are some citations for the use of Cairn equipment in biological research.
They are sorted by product to give easy access to the most relevant papers. Additionally we would suggest searching www.scholar.google.com for “cairn research” alongside any other keyword.
OptoSplit II
2018
January – Kinetic analysis of single molecule FRET transitions without trajectories
February – Single-Particle Tracking of Cell Surface Proteins
February – Single-Molecule FRET Assay to Observe the Activity of Proteins Involved in RNA/RNA Annealing
April – Investigation of the flow structure in thin polymer films using 3D µPTV enhanced by GPU
October – The architecture of EGFR’s basal complexes reveals autoinhibition mechanisms in dimers and oligomers
2017
January – T-type Ca2+ channels are required for enhanced sympathetic axon growth by TNFα reverse signalling
September – Single Molecule FRET Analysis of DNA Binding Proteins
September – Single-Molecule Fluorescence Microscopy in Living Caenorhabditis elegans
September – Role of FK506-binding protein in Ca2+ Spark regulation
October – Role of FK506-binding protein in Ca2+ spark regulation
October – Nanoscale Membrane Budding Induced by CTxB and Detected via Polarized Localization Microscopy
October – Studying Structural Dynamics of Potassium Channels by Single-Molecule FRET
November – Development and characterisation of a novel glucagon like peptide-1 receptor antibody
December – Utilizing Single-Molecule Fret Methods to Study Conformational Changes in Trim5α
2016
February – Galanin inhibits GLP-1 and GIP secretion via the GAL1 receptor in enteroendocrine L and K cells
April – Mechanisms of the Human Telomerase Catalytic Cycle
April – Imaging Membrane Potential with Two Types of Genetically Encoded Fluorescent Voltage Sensors
May – Secretory cargo sorting by Ca2+-dependent Cab45 oligomerization at the trans-Golgi network
July – Rab11 Regulates the Mast Cell Exocytic Response
July – Cardiomyocytes from induced pluripotent stem cells from patients and methods of use thereof
July – Calcium influx through CRAC channels controls actin organization and dynamics at the immune synapse
July – TOR complex 2 localises to the cytokinetic actomyosin ring and controls the fidelity of cytokinesis
September – Dysferlin-mediated phosphatidylserine sorting engages macrophages in sarcolemma repair
September – High cell-surface density of HER2 deforms cell membranes
October – How to Measure Separations and Angles Between Intramolecular Fluorescent Markers
October – Time-resolved and polarised microspectroscopy of thin films of bio- and nanomaterials
November – Single-Particle FRET Microscopy of Immobilized Nucleosomes: Technique Development
November – Revealing calcium fluxes by analyzing inhibition dynamics in action potential clamp
December – Chitin oligomers for use in promoting non-leguminous plant growth and development
2015
February – Activation of Symbiosis Signaling by Arbuscular Mycorrhizal Fungi in Legumes and Rice
March – The Lantibiotic Nisin Induces Lipid II Aggregation, Causing Membrane Instability and Vesicle Budding
April – The Mechanical Properties of Early Drosophila Embryos Measured by High-Speed Video Microrheology
April – Adenylyl cyclases 5 and 6 underlie PIP3-dependent regulation
May – Novel organic dyes for multicolor localization-based super-resolution microscopy
June – Induktion von Granzym B in humanen B-Zellen durch virale Antigene
June – Optical detection of two-color-fluorophore barcode for nanopore DNA sensing
July – Inside-out Ca2+ signalling prompted by STIM1 conformational switch
August – Cdc42 and RhoA reveal different spatio-temporal dynamics upon local stimulation with Semaphorin-3A
September – Inhibition of monocarboxylate transporter by N-cyanosulphonamide S0859
October – Optimized measurements of separations and angles between intra-molecular fluorescent markers
November – Methods, systems and apparatus for size-based particle separation
November – Correction of a Depth-Dependent Lateral Distortion in 3D Super-Resolution Imaging
November – Single Particle Tracking Reveals that EGFR Signaling Activity Is Amplified in Clathrin-Coated Pits
November – Developing Fast Fluorescent Protein Voltage Sensors by Optimizing FRET Interactions
– Synthesis and Secretion of Incretins from the Gut
– Dynamics and Interactions of Individual Proteins in the Membrane of Single, Living Cells
– Simultaneous calcium imaging of multiple neurons in Caenorhabditis elegans
OptoSplit III
OptoLED
2017
February – How activity dependent feedback inhibition may maintain head direction signals in mouse presubiculum
February – Control of Amygdala Circuits by 5-HT Neurons via 5-HT and Glutamate Cotransmission
February – A sweet taste receptor-dependent mechanism of glucosensing in hypothalamic tanycytes
May – Global Representations of Goal-Directed Behavior in Distinct Cell Types of Mouse Neocortex
July – Optical Interrogation And Control of Dynamic Biological Functions
September – Cortical afferents onto the nucleus Reticularis thalami promote plasticity of low-threshold excitability through GluN2C-NMDARs
September – Astrocyte mediated neuronal synchronisation properties revealed by false gliotransmitter release
October – Unveiling some FDA-approved drugs as inhibitors of the store-operated Ca2+ entry pathway
December – Genetically Encoded Calcium Indicators And Methods of Use
2016
March – Light-evoked hyperpolarization and silencing of neurons by conjugated polymers
August – Selective Inhibition Mediates the Sequential Recruitment of Motor Pools
September – Mice produced by mitotic reprogramming of sperm injected into haploid parthenogenotes
October – Mechanisms of CO2/H+ Sensitivity of Astrocytes
October – Cortical Control of Striatal Dopamine Transmission via Striatal Cholinergic Interneurons
December – Treatment of retinal degeneration using gene therapy
2015
March – Prefrontal and Auditory Input to Intercalated Neurons of the Amygdala
April – Rebuilding a realistic corticostriatal “social network” from dissociated cells
April – Novel method to assess axonal excitability using channelrhodopsin-based photoactivation
August – Whole-central nervous system functional imaging in larval Drosophila
OptoScan
2018
September – Spinning-disc confocal microscopy in the second near-infrared window (NIR-II)
May – Dendritic Ca2+ dynamics and multi-modal processing in a cricket antennal interneuron
March – Modeling Short QT Syndrome Using Human‐Induced Pluripotent Stem Cell–Derived Cardiomyocytes
November – EFHB is a Novel Cytosolic Ca2+ Sensor That Modulates STIM1-SARAF Interaction
2017
February – Use of P2X Purinergic Receptor Agonists to Enhance Insulin Secretion In Pancreatic Beta Cells
February – A sweet taste receptor-dependent mechanism of glucosensing in hypothalamic tanycytes
March – Multiple AMPK activators inhibit L-Carnitine uptake in C2C12 skeletal muscle myotub
August – Amino Acid Sensing in Hypothalamic Tanycytes via Umami Taste Receptors
September – CXCL1 activates TRPV1 via Gi/o protein and actin filaments
September – Temporally precise single-cell-resolution optogenetics
September – Physiological Research Pre-Press Article
September – First draft genome sequence of a strain belonging to the Zoogloea genus and its gene expression in situ
October – Mitochondrial Dysfunction in Parkinsonian Mesenchymal Stem Cells Impairs Differentiation
2016
February – Sensing Cardiac Electrical Activity With a Cardiac Myocyte-Targeted Optogenetic Voltage Indicator
August – Agonist-induced sensitisation of the irritant receptor ion channel TRPA1
August – Intracellular pH response to weak acid stress in individual vegetative Bacillus subtilis cells
August – The TRPM2 ion channel is required for sensitivity to warmth
October – Monomeric Alpha-Synuclein Exerts a Physiological Role on Brain ATP Synthase
October – Evidence for Altered Ca2+ Handling in Growth Associated Protein 43-Knockout Skeletal Muscle
October – Monomeric Alpha-Synuclein Exerts a Physiological Role on Brain ATP Synthase
October – Effects of menthol on rat tail artery mediated by TRPM8 and voltage-gated calcium channels
November – In vivo characterization of distinct modality-specific subsets of somatosensory neurons using GCaMP
November – Glycosides from edible sea cucumbers stimulate macrophages via purinergic receptors
December – Glycosides from edible sea cucumbers stimulate macrophages via purinergic receptors
December – Novel temperature-sensitive fluorescent compound and application thereof
– Calcium Imaging to Study NMDA Receptor-mediated Cellular Responses
2015
January – Using siRNA to define functional interactions between melanopsin and multiple G Protein partners
February – HCO3−-independent pH Regulation in Astrocytes in Situ Is Dominated by V-ATPase
March – Propagation of Intracellular Ca 2+ Signals in Aged Exocrine Cells
May – Circulating Pneumolysin Is a Potent Inducer of Cardiac Injury during Pneumococcal Infection
September – Intracellular zinc is a critical intermediate in the excitotoxic cascade
November – Imaging fictive locomotor patterns in larval Drosophila
OptoPatch
2016
March – Wbp2 is required for normal glutamatergic synapses in the cochlea and is crucial for hearing
April – Functional identification of a new opsin as photopigment
April – Time-invariant feed-forward inhibition of Purkinje cells in the cerebellar cortex in vivo
June – Piezo1 haploinsufficiency does not alter mechanotransduction in mouse cochlear outer hair cells
June – In vivo physiological recording from the lateral line of juvenile zebrafish
November – Revealing calcium fluxes by analyzing inhibition dynamics in action potential clamp
2015
March – Calcium-Induced Calcium Release during Action Potential Firing in Developing Inner Hair Cells
September – Hair cell-type dependent expression of basolateral ion channels shapes response dynamics in the frog utricle
November – Membrane properties specialize mammalian inner hair cells for frequency or intensity encoding
Optogenetics
2016
August – Selective Inhibition Mediates the Sequential Recruitment of Motor Pools
October – Mechanisms of CO2/H+ Sensitivity of Astrocytes
October – Cortical Control of Striatal Dopamine Transmission via Striatal Cholinergic Interneurons
December – Treatment of retinal degeneration using gene therapy
TwinCam
LaserBank
Systems
Monochromator
2018
January – CXCL1 activates TRPV1 via Gi/o protein and actin filaments
March – KEAP1 inhibition is neuroprotective and suppresses the development of epilepsy
April – Mitochondrial dysfunction in Parkinsonian mesenchymal stem cells impairs differentiation
June – Insights into the HyPer biosensor as molecular tool for monitoring cellular antioxidant capacity